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Abstract Title:

REM sleep deprivation impairs muscle regeneration in rats.

Abstract Source:

Growth Factors. 2017 Feb ;35(1):12-18. Epub 2017 Apr 17. PMID: 28415893

Abstract Author(s):

Marcos Mônico-Neto, Murilo Dáttilo, Daniel Araki Ribeiro, Kil Sun Lee, Marco Túlio de Mello, Sergio Tufik, Hanna Karen Moreira Antunes

Article Affiliation:

Marcos Mônico-Neto

Abstract:

INTRODUCTION: The aim was observe the influence of sleep deprivation (SD) and sleep recovery on muscle regeneration process in rats submitted to cryolesion.

METHODS: Thirty-two Wistar rats were randomly allocated in four groups: control (CTL), SD for 96 h (SD96), control plus sleep recovery period (CTL + R) and SD96h plus 96 h of sleep recovery (SD96 + R). The animals were submitted to muscle injury by cryolesioning, after to SD and sleep recovery.

RESULTS: The major outcomes of this study were the reduction of muscular IGF-1 in both legs (injured and uninjured) and a delay in muscle regeneration process of animals submitted to SD compared to animals that slept, with increase connective tissue, inflammatory infiltrate and minor muscle fibers.

CONCLUSIONS: SD impairs muscle regeneration in rats, moreover reduces muscular IGF-1 and sleep recovery was able to restore it to basal levels, but it was not enough to normalize the muscle regeneration.

Study Type : Animal Study
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