Abstract Title:

Small-cell lung cancer exhibiting spontaneous regression.

Abstract Source:

Intern Med. 2013 ;52(19):2249-52. Epub 2012 Mar 1. PMID: 24088761

Abstract Author(s):

Shin-ichiro Iwakami, Mitsuhiro Fujii, Toshiji Ishiwata, Naoko Iwakami, Munechika Hara, Hiroaki Ihara, Ryo Wada, Takeo Tsutsumi, Kuniaki Seyama, Kazuhisa Takahashi

Article Affiliation:

Shin-ichiro Iwakami


A 56-year-old woman was admitted to our hospital because a chest X-ray and thoracic computed tomography (CT) scan revealed a heterogeneous tumor in the middle mediastinum during a visit to a nearby clinic for a consultation regarding a persistent cough and body weight loss. However, the tumor spontaneously decreased on thoracic CT performed on admission. Subsequently, a biopsy of the tumor using video-assisted thoracoscopy was performed. The pathological findings disclosed the tumor to be small-cell lung cancer with infiltration of CD8-positive T-cells exhibiting spontaneous regression. Cell-mediated immunity, including CD8-positive T-cells, may have relevance to the spontaneous regression of malignant tumors.

Study Type : Human: Case Report

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