Abstract Title:

Cytotoxicities of sodium benzoate in primary culture of hepatocytes from adult rat liver.

Abstract Source:

Tohoku J Exp Med. 1987 May;152(1):47-51. PMID: 2887046

Abstract Author(s):

K Oyanagi, Y Kuniya, M Nagao, A Tsuchiyama, T Nakao


The cytotoxicities of sodium benzoate was studied using primary culture of hepatocytes established from adult rat liver by a collagenase perfusion technique and maintained as a monolayer in serum-free culture medium. The activities of ornithine transcarbamylase (as a marker of mitochondria) and tyrosine aminotransferase (as a marker of cytosol) were clearly suppressed by sodium benzoate at concentration in excess of 500 micrograms/ml. Intracellular protein synthesis and DNA synthesis were also suppressed, and the suppression of DNA synthesis was observed even with a lower concentration of benzoate (100 micrograms/ml).

Study Type : In Vitro Study
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