Abstract Title:

Short-term effect of sodium benzoate in F344 rats and B6C3F1 mice.

Abstract Source:

Toxicol Lett. 1993 Aug;69(2):171-9. PMID: 8212059

Abstract Author(s):

T Fujitani

Article Affiliation:

Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Japan.

Abstract:

F344 rats and B6C3F1 mice of each sex were administered 0, 1.81, 2.09 or 2.40% (for rats) and 0, 2.08, 2.50 or 3.00% (for mice) of sodium benzoate in the diet for 10 days. In male rats of the 2.4% group, relative liver and kidney weight, serum levels of albumin, total protein and gamma-glutamyl transpeptidase were significantly increased and enlarged hepatocytes with glassy cytoplasm were seen using light microscopy. In male mice of the 3.0% group, absolute liver weights and serum cholesterol and phospholipid levels were significantly increased, and enlargement, vacuolation and necrosis of hepatocytes were evident.

Study Type : Animal Study
Additional Links

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.