Abstract Title:

Soybean peptide lunasin suppresses in vitro and in vivo 7,12-dimethylbenz[a]anthracene-induced tumorigenesis.

Abstract Source:

Cancer Prev Res (Phila). 2010 Dec;3(12):1586-95. Epub 2010 Sep 17. PMID: 21535606

Abstract Author(s):

Chia-Chien Hsieh, Blanca Hernández-Ledesma, Ben O de Lumen

Article Affiliation:

Authors are from the Dept. of Nutritional Science and Toxicology, Univ. of California at Berkeley, 119 Morgan Hall, Berkeley, CA 94720-3104, U.S.A. Direct inquiries to author de Lumen (E-mail: [email protected]).

Abstract:

Lunasin is a novel peptide identified in soybean and other seeds. This study evaluated the anti-tumorigenic effects of lunasin on 7,12-dimethylbenz(a)anthracene (DMBA) and 3-methylcholanthrene-treated (MCA) fibroblast NIH/3T3 cells. Lunasin significantly inhibited cell proliferation and cancerous foci formation in these 2 chemical carcinogens-treated cells. An in vivo SENCAR mouse model induced with DMBA was used to study the mammary cancer preventive properties of dietary lunasin contained in soy protein. Tumor incidence was 67% and 50%, and the tumor generation was 1.88± 0.48 and 1.17 ± 0.17, respectively, for the mice fed control diet and experimental diet obtained after AIN-93G supplementation with lunasin-enriched soy protein concentrate (containing 0.23% lunasin). However, no effects were observed in mice fed AIN-93G supplemented with soy protein concentrate(containing 0.15% lunasin). The data provided illustrate the anticancer potential of lunasin both in vitro and in vivo and supports the recommendation of soy protein as a dietary component that may aid in the prevention of mammary cancer. Practical Application:  Daily intake of lunasin-enriched soy protein is introduced as a promising strategy to prevent chemical carcinogens-induced mammary tumors.

Study Type : Animal Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.