Article Publish Status: FREE
Abstract Title:

Antiemetic activity of volatile oil from Mentha spicata and Mentha× piperita in chemotherapy-induced nausea and vomiting.

Abstract Source:

Ecancermedicalscience. 2013 ;7:290. Epub 2013 Jan 31. PMID: 23390455

Abstract Author(s):

Z Tayarani-Najaran, E Talasaz-Firoozi, R Nasiri, N Jalali, Mk Hassanzadeh

Article Affiliation:

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad 91775-1365, Iran.

Abstract:

BACKGROUND: This study is aimed at determining the efficacy of Mentha spicata (M. spicata) and Mentha× piperita (M. × piperita) in preventing chemotherapy-induced nausea and vomiting (CINV).

METHODS: This was a randomised, double-blind clinical trial study. Prior to the study, patients were randomly assigned into four groups to receive M. spicata or M.× piperita. Statistical analysis included the χ(2) test, relative risk, and Student's t-test. Fifty courses were analysed for each group that met our eligibility criteria. The treatment and placebo groups applied essential oils of M. spicata, M. × piperita, or a placebo, while the control group continued with their previous antiemetic regimen. Patients or guardians recorded the number of emetic events, the intensity of nausea over 20 h of chemotherapy, as well as any possible adverse effects that occurred during this time.

RESULTS: There was a significant reduction in the intensity and number of emetic events in the first 24 h with M. spicata and M.× piperita in both treatment groups (p<0.05) when compared with the control and no adverse effects were reported. The cost of treatment was also reduced when essential oils were used.

CONCLUSION: M. spicata or M.× piperita essential oils are safe and effective for antiemetic treatment in patients, as well as being cost effective.

Study Type : Human Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.