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Abstract Title:

Inhibitory effect of glycolipids from spinach on in vitro and ex vivo angiogenesis.

Abstract Source:

Oncol Rep. 2005 Jul;14(1):157-60. PMID: 15944783

Abstract Author(s):

Kiminori Matsubara, Hiroaki Matsumoto, Yoshiyuki Mizushina, Masaharu Mori, Nobuyoshi Nakajima, Michiko Fuchigami, Hiromi Yoshida, Takahiko Hada

Abstract:

Full Citation: "Anti-cancer activity of some glycolipids from animals and plants has been demonstrated, although it was unknown whether the glycolipids had anti-angiogenic activity. The effects of the purified three glycolipids, monogalactosyl diacylglycerol (MGDG), digalactosyl diacylglycerol (DGDG), and sulfoquinovosyl diacylglycerol (SQDG) from the green vegetable spinach (Spinacia oleracea L.) were examined on in vitro and ex vivo angiogenesis models. MGDG and SQDG suppressed microvessel growth in an ex vivo angiogenesis model using a rat aortic ring. The glycolipids inhibited human umbilical vein endothelial cell (HVUEC) tube formation on a reconstituted basement membrane and HUVEC proliferation. These results demonstrate that glycolipids from spinach would suppress tumor growth by suppressing angiogenesis and might be candidates for anti-cancer or anti-angiogenic materials.."

Additional Links
Pharmacological Actions : Anti-Angiogenic : CK(282) : AC(192)

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Sayer Ji
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