Article Publish Status: FREE
Abstract Title:

Regulatory Efficacy ofProtease Hydrolyzate on Lipid Metabolism and Gut Microbiota in High-Fat Diet-Fed Rats.

Abstract Source:

Int J Mol Sci. 2018 Dec 13 ;19(12). Epub 2018 Dec 13. PMID: 30551559

Abstract Author(s):

Pengpeng Hua, Zhiying Yu, Yu Xiong, Bin Liu, Lina Zhao

Article Affiliation:

Pengpeng Hua


Lipid metabolism disorder (LMD) is a public health issue.is a widely used natural weight-reducing agent andis a kind of protein source. In the present study, we aimed to evaluate the effect ofprotease hydrolyzate (SPPH) on the lipid metabolism and gut microbiota in high-fat diet (HFD)-fed rats. Our study showed that SPPH decreased the levels of triglyceride (TG), total cholesterol (TC), low-density-lipoprotein cholesterol (LDL-c), alanine transaminase (ALT), and aspartate transaminase (AST), but increased the level of high-density-lipoprotein cholesterol (HDL-c) in serum and liver. Moreover, SPPH had a hypolipidemic effect as indicated by the down-regulation of sterol regulatory element-binding transcription factor-1c (SREBP-1c), acetyl CoA carboxylase (ACC), SREBP-1c, and peroxisome proliferator-activated receptor-γ (PPARγ) and the up-regulation of adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) and peroxisome proliferator-activated receptorα (PPARα) at the mRNA level in liver. SPPH treatment enriched the abundance of beneficial bacteria. In conclusion, our study showed that SPPH might beproduce glucose metabolic benefits in rats with diet-induced LMD. The mechanisms underlying the beneficial effects of SPPH on the metabolism remain to be further investigated. Collectively, the above-mentioned findings illustrate that Spirulina platensis peptides have the potential to ameliorate lipid metabolic disorders, and our data provides evidence that SPPH might be used as an adjuvant therapy and functional food in obese and diabetic individuals.

Study Type : Animal Study

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