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Article Publish Status: FREE
Abstract Title:

Spirulina platensis prevents oxidative stress and inflammation promoted by strength training in rats: dose-response relation study.

Abstract Source:

Sci Rep. 2020 Apr 14 ;10(1):6382. Epub 2020 Apr 14. PMID: 32286405

Abstract Author(s):

Aline de Freitas Brito, Alexandre Sérgio Silva, Caio Victor Coutinho de Oliveira, Alesandra Araújo de Souza, Paula Benvindo Ferreira, Iara Leão Luna de Souza, Layanne Cabral da Cunha Araujo, Gustavo da Silva Félix, Renata de Souza Sampaio, Renata Leite Tavares, Reabias de Andrade Pereira, Manoel Miranda Neto, Bagnólia Araújo da Silva

Article Affiliation:

Aline de Freitas Brito

Abstract:

The purpose of this study was to evaluate the effects of Spirulina Platensis supplementation on selected blood markers of oxidative stress, muscle damage, inflammation, and performance in trained rats. Rats (250 g - 300 g) were submitted to a strength training program (eight weeks), divided into four groups: control (GT) (trained without supplementation), trained with daily-supplementation of 50 mg/kg (GT50), 150 mg/kg (GT150) and 500 mg/kg (GT500). Training consisted of a jump protocol in PVC-cylinder containing water, with increasing load over experimental weeks. We evaluated the markers of oxidative stress (malondialdehyde - MDA and antioxidant capacity) and inflammation (C-reactive protein) at the end of the training. Among groups submitted to strength training, concentration of C-reactive protein decreased after 8 weeks of intervention in the trained group and GT500. Strength training enhanced plasma MDA concentration of malondialdehyde with supplementation of S. platensis in GT150 and GT500. In plasma analysis, strength training enhanced the percentage of oxidation inhibition, with spirulina supplementation in rates of 150 and 500 mg/kg. Spirulina supplementation for 8 weeks (in a dose-effect manner) improved antioxidant capacity as well as attenuated exercise-induced increases in ROS and inflammation. As a practical application, the use as high doses did not cause a reduction in positive physiological adaptations to exercise training. Additional studies are necessary to test the application of Spirulina Platensis in other contexts, as collective sports (basketball, football, soccer).

Study Type : Animal Study

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