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Article Publish Status: FREE
Abstract Title:

Spontaneous pathological complete regression of high-grade triple-negative breast cancer with axillary metastasis.

Abstract Source:

Pol J Pathol. 2019 ;70(2):139-143. PMID: 31556565

Abstract Author(s):

Gábor Cserni, Orsolya Serfozo, Éva Ambrózay, László Markó, László Krenács

Article Affiliation:

Gábor Cserni

Abstract:

We report on a breast carcinoma with medullary features diagnosed by core needle biopsy in a 72-year-old woman. Both the primary tumour and its fine needle aspiration-proven, rapidly growing axillary metastasis regressed completely in less than 2 months, by the time surgery was performed. The biopsy of the primary tumour demonstrated a dense stromal infiltrate of CD8+/granzyme B+ activated cytotoxic T-cells suggestive of a robust antitumour immune response. Paradoxically, both tumour cells and tumour infiltrating immune cells demonstrated a diffuse PD-L1 expression, revealing that antitumour immune response has the ability to spontaneously overcome inhibitory mechanisms induced by cancerous growth.

Study Type : Human: Case Report

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