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Abstract Title:

Spontaneous regression of meningiomas after interruption of nomegestrol acetate: a series of three patients.

Abstract Source:

Acta Neurochir (Wien). 2019 04 ;161(4):761-765. Epub 2019 Feb 19. PMID: 30783806

Abstract Author(s):

Thibault Passeri, Pierre-Olivier Champagne, Anne-Laure Bernat, Shunya Hanakita, Henri Salle, Emmanuel Mandonnet, Sébastien Froelich

Article Affiliation:

Thibault Passeri

Abstract:

BACKGROUND: The relationship between increased meningioma incidence and growth and long-term hormonal therapy with cyproterone acetate (CPA) in women has been recently established in literature. Following the raise in awareness from hormonal treatment, we describe a potential relationship between the progesterone agonist nomegestrol acetate (NOMAC) and meningioma growth.

METHODS: After implementation of a screening protocol to detect potential interactions between hormonal exposure and occurrence of meningioma, we identified patients taking NOMAC and newly diagnosed with a meningioma. NOMAC was stopped and those patients were followed tightly both clinically and radiologically. Retrospective volumetric analysis of the tumors was performed on the imaging.

RESULTS: Three patients were identified for the study. After cessation of the NOMAC, tumor shrinkage was documented for all meningiomas within the first month. Up to 70% of tumor volume reduction was observed during the first year of follow-up in one of them. None of the patients developed new symptoms.

CONCLUSION: We report the first cases of meningiomas responsiveness to discontinuation of hormonal therapy with NOMAC. Similarly to cases associated with long-term CPA intake, tumor reduction, and improvement of clinical symptoms can be observed after cessation of NOMAC.

Study Type : Human: Case Report

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