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Article Publish Status: FREE
Abstract Title:

Spontaneous regression of small cell lung cancer combined with cancer associated retinopathy.

Abstract Source:

Lung Cancer. 2015 Jan ;87(1):73-6. Epub 2014 Nov 3. PMID: 25468200

Abstract Author(s):

Hidenori Kitai, Jun Sakakibara-Konishi, Satoshi Oizumi, Yoshihiko Hirohashi, Wataru Saito, Atsuhiro Kanda, Noriyuki Sato, Masaharu Nishimura

Article Affiliation:

Hidenori Kitai

Abstract:

Spontaneous regression (SR) is defined as the complete or partial disappearance of disease without anticancer treatments. We report a case of SR of small cell lung cancer (SCLC) combined with cancer associated retinopathy (CAR). A 65-year-old woman was admitted to our hospital to examine abnormal shadows of the lung with visual loss. She was diagnosed with SCLC associated with CAR. Subsequent chest X-ray and CT scan showed partial regression of both primary tumor and lymph node metastasis without anticancer treatment. Recoverin antigen was present on the tumor cells and anti-recoverin antibody was observed in the patient's serum. Activation of recoverin-specific antitumor cytotoxic T lymphocyte (CTL) was observed in this patient. SCLC was considered to reduce spontaneously by the activation of recoverin-specific antitumor CTL. To the best of our knowledge, this is the first report of SR in SCLC combined with CAR.

Study Type : Human: Case Report

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