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Abstract Title:

Meta-analysis of regression of advanced solid tumors in patients receiving placebo or no anti-cancer therapy in prospective trials.

Abstract Source:

Crit Rev Oncol Hematol. 2016 Feb ;98:122-36. Epub 2015 Nov 9. PMID: 26597016

Abstract Author(s):

Pooja Ghatalia, Charity J Morgan, Guru Sonpavde

Article Affiliation:

Pooja Ghatalia

Abstract:

BACKGROUND: A meta-analysis of prospective trials systematically investigated regression of advanced solid tumors in patients receiving placebo or no anticancer therapy to inform on spontaneous regressions.

PATIENT AND METHODS: Arms of randomized controlled trials (RCTs) of metastatic solid tumors receiving placebo or no anti-cancer therapy were used. Statistical analyses were conducted to calculate the overall response rate (ORR) and to detect differentials based on histology, progression at baseline and prior therapies.

RESULTS: A total of 7676 patients were evaluable from 61 RCTs evaluating 18 solid tumors. The ORR was 1.95% (95% CI: 1.52-2.48%). There was no significant effect of histology (p=0.110), baseline progressive disease (p>0.20) or the line of therapy (p>0.20) on ORR.

CONCLUSIONS: Spontaneous regressions are seen across all advanced solid tumors. Some malignancies demonstrated higher rates of spontaneous regressions and may be relatively immunotherapy responsive.

Study Type : Meta Analysis

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Sayer Ji
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