Squamous cell carcinoma in ulcer after bacille Calmette-Guérin vaccination. - GreenMedInfo Summary
[Squamous cell carcinoma in ulcer after bacille Calmette-Guérin vaccination].
Ugeskr Laeger. 2014 Oct 13 ;176(42). PMID: 25316362
Rikke Maria Nielsen
Marjolin's ulcer is an aggressive squamous cell carcinoma (SCC) found in chronically inflamed skin. SCC has been reported in smallpox vaccination sites, whereas basal cell carcinomas are more common in scar after bacille Calmette-Guérin (BCG) vaccination. A 72-year-old man presented with a chronic ulcer at the site of his childhood BCG vaccination. At the time of examination, a 3 × 1.5 cm fleshy and secreting ulcer was found on the shoulder. Biopsy revealed SCC, and the tumour was surgically removed. In conclusion, chronic ulcers, especially those originating in chronically inflamed skin, should be regularly biopsied to assure that malignant transformation has not occurred.