Article Publish Status: FREE
Abstract Title:

Stability and anti-proliferative properties of biologically active compounds extracted from Cistus L. after sterilization treatments.

Abstract Source:

Sci Rep. 2020 04 16 ;10(1):6521. Epub 2020 Apr 16. PMID: 32300137

Abstract Author(s):

Mario Ammendola, Monika Haponska, Karolina Balik, Paulina Modrakowska, Karolina Matulewicz, Lukasz Kazmierski, Aleksandra Lis, Justyna Kozlowska, Ricard Garcia-Valls, Marta Giamberini, Anna Bajek, Bartosz Tylkowski

Article Affiliation:

Mario Ammendola


The growing interest of oncologists in natural compounds such as polyphenols and flavonoids is encouraging the development of innovative and efficient carriers for the delivery of those drugs. This study examines carboxymethyl chitosan-based microcapsules created by spray drying as a method for delivering biologically active compounds isolated from the Cistus herb. Effects of sterilization and encapsulation on the polyphenol and flavonoid content of Cistus extract were investigated to optimize the production process. Furthermore, in vitro studies were carried out to examine the anticancer properties of sterilized polyphenols and flavonoids on glioblastoma cells isolated from oncological patients. Acquired results show high anticancer potential towards glioblastoma as well as low cytotoxicity towards non-cancer cell lines by the substances in question. Steam sterilization is shown to affect the content of biologically active compounds the least. We demonstrate that the investigated form of drug encapsulation is both efficient and potentially possible to scale up from the viewpoint of the pharmaceutical industry.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Antiproliferative : CK(6801) : AC(5032)

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