Abstract Title:

The standardized extract of Ziziphus jujuba fruit (jujube) regulates pro-inflammatory cytokine expression in cultured murine macrophages: suppression of lipopolysaccharide-stimulated NF-κB activity.

Abstract Source:

Phytother Res. 2014 Oct ;28(10):1527-32. Epub 2014 May 8. PMID: 24806434

Abstract Author(s):

Jianping Chen, Crystal Y Q Du, Kelly Y C Lam, Wendy L Zhang, Candy T W Lam, Artemis L Yan, Ping Yao, David T W Lau, Tina T X Dong, Karl W K Tsim

Article Affiliation:

Jianping Chen

Abstract:

The fruit of Ziziphus jujuba Mill., known as jujube or Chinese date, is commonly consumed as a health supplement or herbal medicine worldwide. To study the beneficial role of jujube in regulating immune response, we investigated its roles on the expressions of pro-inflammatory cytokines in cultured macrophages. Application of chemically standardized jujube water extract for 24 h stimulated the transcriptional expression of interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α in cultured RAW 264.7 macrophages. In contrast, the pretreatment with jujube water extract suppressed the expression of IL-1β and IL-6, but not for TNF-α in lipopolysaccharide (LPS)-stimulated macrophages. The IL-1β and IL-6 cytokines in LPS-induced macrophages were suppressed by jujube water extract in both mRNA and protein levels. In parallel, the inhibition of jujube water extract on the transcriptional activity of nuclear factor-kappa B was revealed in LPS-induced macrophages. These results verified the bidirectional immune-modulatory roles of jujube by regulating the expressions of pro-inflammatory cytokines in macrophages.

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