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Abstract Title:

HMG CoA reductase inhibitors affect Na(+)-H+ antiport activity in human lymphoblasts.

Abstract Source:

Am J Physiol. 1991 Nov ;261(5 Pt 1):C780-6. PMID: 1659206

Abstract Author(s):

L L Ng, J E Davies

Article Affiliation:

Department of Pharmacology, Leicester Royal Infirmary, University of Leicester, United Kingdom.

Abstract:

The Na(+)-H+ antiport is a membrane-bound glycoprotein that extrudes intracellular acid loads and regulates cellular volume. Cellular synthesis of the oligosaccharide side chains of glycoproteins is dependent on a supply of mevalonate, itself a product of the rate-limiting enzyme of cholesterol synthesis 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase. The effect of two HMG CoA reductase inhibitors (simvastatin and 25-hydroxycholesterol) on intracellular pH and Na(+)-H+ exchange was therefore studied. Inhibition of the Na(+)-H+ antiport by these agents led to a fall in intracellular pH but did not impair the regulatory volume increase response to a hypertonic stimulus. The inhibitory effect of simvastatin was prevented by mevalonate but not dolichol or squalene. The effect of 25-hydroxycholesterol was more complex and not easily reversed. Thus HMG CoA reductase inhibitors reduced the ability of human lymphoblasts to expel an intracellular acid load via the Na(+)-H+ antiport, although the response of the antiport to an osmotic stimulus was preserved.

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Sayer Ji
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