Statin-induced fibrotic nonspecific interstitial pneumonia has been reported. - GreenMedInfo Summary
Statin-induced fibrotic nonspecific interstitial pneumonia.
Eur Respir J. 2002 Mar ;19(3):577-80. PMID: 11936540
Dept of Cellular Pathology, Centre Hospitalier Universitaire de Grenoble, Université J. Fourier, France.
Statins inhibit the 3-hydroxy-3-methylglutaryl coenzyme A reductase, reduce the serum level of low-density lipoprotein cholesterol, and are extensively prescribed to prevent cardiovascular mortality and morbidity. Few systemic adverse effects, such as pseudopolymyositis, lupus-like syndromes, and anecdotal hypersensitivity pneumonitis, have been reported. A simvastatin-induced diffuse interstitial pneumonia associated with a nonspecific interstitial pneumonia pattern at histological analysis is repoted here. Ultrastructural analysis showed a diffuse cytoplasmic accumulation of intralysosomial lamellar inclusions in type II pneumonocytes, histiocytes and endothelial cells, suggesting a shared pathogenesis with amphiphilic drug-induced toxic lung injury. Because statins are increasingly prescribed, statin-induced interstitial lung disorders may be more frequently observed and early recognition will be required.