Abstract Title:

Statin Use and the Risk of Type 2 Diabetes Mellitus in Children and Adolescents.

Abstract Source:

Acad Pediatr. 2017 Feb 20. Epub 2017 Feb 20. PMID: 28232259

Abstract Author(s):

Nina Joyce, Justin P Zachariah, Charles B Eaton, Amal N Trivedi, Gregory A Wellenius

Article Affiliation:

Nina Joyce


OBJECTIVE: There is increasing evidence of an association between statin use and type 2 diabetes (T2DM) in adults, yet this relationship has never been studied in children or adolescents and may have important implications for assessing risks and benefits of treatment in this population."We estimated the association between statin use and the risk of T2DMin children with and without a dyslipidemia diagnosis.

METHODS: Propensity scores were used to match new users of statins with a minimum 50 percent of days covered (PDC) in the first year of use to up to 10 non-users. Analyses were stratified by a dyslipidemia diagnosis based on recent evidence suggesting a potentially protective effect of familial hypercholesterolemia on T2DM. In sensitivity analyses we varied this period of exclusion and PDC. Cox proportional hazard models compared the hazard of the outcome between the exposed and unexposed patients.

RESULTS: A total of 21,243,305 patients met eligibility criteria, 2,085 (0.01%) of whom met the exposure definition of which 1,046 (50%) had a dyslipidemia diagnosis. Statin use was associated with an increased risk of type 2 diabetes in children without dyslipidemia (HR 1.96, 95% CI 1.20-3.22), but not in children with a dyslipidemia (HR 1.11, 95% CI 0.65-1.90). The results were consistent across variations in the exclusion period and PDC.

CONCLUSIONS: Statin use was associated with an increased likelihood of developing T2DM in children without dyslipidemia. Physicians and patients need to weigh the possible risk of T2DM against the long-term benefits of statin therapy at a young age.

Study Type : Human Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.