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Abstract Title:

Anti-inflammatory Flavonoids Isolated from Passiflora foetida.

Abstract Source:

Nat Prod Commun. 2015 Jun ;10(6):929-31. PMID: 26197519

Abstract Author(s):

Thi Yen Nguyen, Dao Cuong To, Manh Hung Tran, Joo Sang Lee, Jeong Hyung Lee, Jeong Ah Kim, Mi Hee Woo, Byung Sun Min

Article Affiliation:

Thi Yen Nguyen

Abstract:

In this study, we evaluated the anti-inflammatory activity of the soluble ethyl acetate fraction and chemical components of the stem bark of Passiflora foetida (Passifloraceae). Ten flavonoids (1-10) were isolated by various chromatographic techniques, and their structures were determined based on spectroscopic analyses by using nuclear magnetic resonance (NMR). Luteolin (2) and chrysoeriol (3) showed the most potent inhibition of nitric oxide (NO) production in macrophage cell line, RAW264.7, with half maximal inhibitor concentration (IC50) values of 1.2 and 3.1μM, respectively. These compounds suppressed lipopolysaccharide (LPS)-induced inducible NO synthase (iNOS) expression at the transcription level. Our research indicates that the stem bark of P. foetida has significant anti-inflammatory properties, suggesting that its flavonoids may have anti-inflammatory benefits.

Study Type : In Vitro Study

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