Abstract Title:

Novel tirucallane triterpenoids from the stem bark of Toona sinensis.

Abstract Source:

Fitoterapia. 2016 Jul ;112:97-103. Epub 2016 May 20. PMID: 27215130

Abstract Author(s):

Jing Tang, Jian Xu, Jie Zhang, Wen-Yuan Liu, Ning Xie, Lei Chen, Feng Feng, Wei Qu

Article Affiliation:

Jing Tang


Phytochemical investigation on the stem bark of Toona sinensis was carried out by various chromatographic techniques resulting in the isolation and elucidation of two novel tirucallane triterpenoids, named (20S)-3-oxo-tirucalla-25-nor-7-en-24-oic acid (1) and (20S)-5α,8α-epidioxy-3-oxo-24-nor-6.9(11)-dien-23-oic acid (2), along with fifteen known triterpenoids (3-17), their structures were determined by extensive spectroscopic methods, including 1D-, 2D-NMR and HR-ESI-MS experiments. Compound 2 is uncommon in nature, which possesses a peroxide bridge cross C-5 and C-8 in the triterpenoid skeleton. All isolated compounds were evaluated for cytotoxicity against five human tumor cell lines (A-549, Hela, HepG2, SGC-7901 and SW-480), among them, compound 17 displayed strongest cytotoxic activity against A-549 cells and the results indicated that its cytotoxicity against A-549 cells was mediated by the intrinsic mitochondrial apoptotic pathway. In addition, ROS production-inhibitory activities were also evaluated, but none of them was active.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Cytotoxic : CK(76) : AC(60)

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