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Abstract Title:

Stem cell-derived exosomes: A promising strategy for fracture healing.

Abstract Source:

Cell Prolif. 2017 Jul 25. Epub 2017 Jul 25. PMID: 28741758

Abstract Author(s):

Zi-Chen Hao, Jun Lu, Shan-Zheng Wang, Hao Wu, Yun-Tong Zhang, Shuo-Gui Xu

Article Affiliation:

Zi-Chen Hao

Abstract:

OBJECTIVES: To describe the biological characteristics of exosomes and to summarize the current status of stem cell-derived exosomes on fracture healing. Meanwhile, future challenges, limitations and perspectives are also discussed.

METHODS: Search and analyze the related articles in pubmed database through the multi-combination of keywords like"stem cells","exosomes","bone regeneration"and"fracture healing".

CONCLUSION: Stem cell-derived exosome therapy for fracture healing has been enjoying popularity and is drawing increasing attention. This strategy helps to promote proliferation and migration of cells, as well as osteogenesis and angiogenesis, in the process of bone formation. Although the exact mechanisms remain elusive, exosomal miRNAs seem to play vital roles. Future studies are required to solve multiple problems before clinical application, including comprehensive and thorough understanding of exosomes, the exact roles of exosomes in regulating bone formation, and the optimal source, dose and frequency of treatment, as well as technical and safety issues. Moreover, studies based on fracture models of large animals are could offer guidance and are in demand.

Study Type : Review
Additional Links
Additional Keywords : Exosomes : CK(35) : AC(10)

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Sayer Ji
Founder of GreenMedInfo.com

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