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Article Publish Status: FREE
Abstract Title:

Stem Cell-Derived Exosomes Prevent Aging-Induced Cardiac Dysfunction through a Novel Exosome/lncRNA MALAT1/NF-B/TNF-Signaling Pathway.

Abstract Source:

Oxid Med Cell Longev. 2019 ;2019:9739258. Epub 2019 Apr 8. PMID: 31089420

Abstract Author(s):

Bao Zhu, Lulu Zhang, Chun Liang, Bin Liu, Xiangbin Pan, Yanli Wang, Yuqing Zhang, Yu Zhang, Wenping Xie, Bing Yan, Feng Liu, Hon-Kan Yip, Xi-Yong Yu, Yangxin Li

Article Affiliation:

Bao Zhu

Abstract:

Aging is a risk factor for cardiovascular disease, and there is no effective therapeutic approach to alleviate this condition. NF-B and TNF-have been implicated in the activation of the aging process, but the signaling molecules responsible for the inactivation of NF-B and TNF-remain unknown. Exosomes have been reported to improve heart functions by releasing miRNA. Recent studies suggest that lncRNAs are more tissue-specific and developmental stage-specific compared to miRNA. However, the role of lncRNA in exosome-mediated cardiac repair has not been explored. In the present study, we focused on metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), which is an lncRNA associated with cell senescence. We discovered that human umbilical cord mesenchymal stem cell- (UMSC-) derived exosomes prevent aging-induced cardiac dysfunction. Silencer RNA against lncRNA MALAT1 blocked the beneficial effects of exosomes. In summary, we discovered that UMSC-derived exosomes prevent aging-induced cardiac dysfunction by releasing novel lncRNA MALAT1, which in turn inhibits the NF-B/TNF-signaling pathway. These findings will lead to the development of therapies that delay aging and progression of age-related diseases.

Study Type : In Vitro Study

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