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Abstract Title:

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice.

Abstract Source:

Science. 2016 Apr 28. Epub 2016 Apr 28. PMID: 27127236

Abstract Author(s):

Hongbo Zhang, Dongryeol Ryu, Yibo Wu, Karim Gariani, Xu Wang, Peiling Luan, Davide D'Amico, Eduardo R Ropelle, Matthias P Lutolf, Ruedi Aebersold, Kristina Schoonjans, Keir J Menzies, Johan Auwerx

Article Affiliation:

Hongbo Zhang

Abstract:

Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to senescence during aging. We demonstrate the importance of the amount of the oxidized form of cellular nicotinamide adenine dinucleotide (NAD(+)) and its impact on mitochondrial activity as a pivotal switch to modulate muscle SC (MuSC) senescence. Treatment with the NAD(+) precursor nicotinamide riboside (NR) induced the mitochondrial unfolded protein response (UPR(mt)) and synthesis of prohibitin proteins, and this rejuvenated MuSCs in aged mice. NR also prevented MuSC senescence in the Mdx mouse model of muscular dystrophy. We furthermore demonstrate that NR delays senescence of neural SCs (NSCs) and melanocyte SCs (McSCs), and increased mouse lifespan. Strategies that conserve cellular NAD(+) may reprogram dysfunctional SCs and improve lifespan in mammals.

Study Type : Animal Study

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Sayer Ji
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