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Abstract Title:

Structural characterization and immunomodulatory activity of an exopolysaccharide produced by Lactobacillus helveticus LZ-R-5.

Abstract Source:

Carbohydr Polym. 2020 May 1 ;235:115977. Epub 2020 Feb 11. PMID: 32122508

Abstract Author(s):

Xiu You, Zhi Li, Kai Ma, Changliang Zhang, Xiaohong Chen, Guangxian Wang, Lin Yang, Mingsheng Dong, Xin Rui, Qiuqin Zhang, Wei Li

Article Affiliation:

Xiu You

Abstract:

Exopolysaccharide (R-5-EPS) was isolated from the fermented milk of Lactobacillus helveticus LZ-R-5 and purified by DEAE-52 cellulose anion-exchange column, and characterization of the structure was conducted. Results showed that R-5-EPS was a heteropolysaccharide containing linear repeating units of→6)-β-D-Galp-(1→3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→3)-β-D-Glcp-(1→ with an average Mw of 5.41 × 10Da. Furthermore, at a cellular level, R-5-EPS showed immunostimulatory activity due to its strong effect on increasing proliferation of RAW264.7 macrophages and enhancing phagocytosis, acid phosphatase activity, nitric oxide production and cytokines production in macrophages. These results suggest that R-5-EPS have a potent immunostimulatory activity and may be explored as a potential immunomodulatory agent.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Immunomodulatory : CK(2249) : AC(733)

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