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Abstract Title:

Structural characterization and immunomodulatory activity of a novel polysaccharide from Ficus carica.

Abstract Source:

Food Funct. 2018 Jul 17 ;9(7):3930-3943. PMID: 29974087

Abstract Author(s):

Juan Du, Jingjing Li, Jianhua Zhu, Chunhua Huang, Sixue Bi, Liyan Song, Xianjing Hu, Rongmin Yu

Article Affiliation:

Juan Du

Abstract:

A novel polysaccharide (FCPW80-2) with a molecular weight of 1.21× 105 Da was first isolated from Ficus carica through hot water extraction and several chromatographic methods. The structure of FCPW80-2 was determined by chemical and instrumental analysis. The results showed that the backbone of FCPW80-2 consists of (1→5)-linked α-l-Ara, (1→3,6)-linked β-d-Man and (1→4,6)-linked β-d-Gal. The branches of FCPW80-2 consist of (1→4)-linked α-d-Glc and (1→3)-linked β-l-Rha terminated with (1→)-linked β-d-Glc. In vitro immunomodulatory activity assays revealed that FCPW80-2 could markedly promote the secretion of cytotoxic molecules (NO) and cytokines (TNF-α and IL-6) as well as the phagocytosis of RAW264.7 macrophages. Moreover, TLR2 was found to be a pattern recognition receptor (PRR) of FCPW80-2, and its related mitogen-activated protein kinases (MAPKs), including p-ERK, p-JNK and p-p38, were rapidly upregulated by FCPW80-2 in RAW264.7 macrophages. Furthermore, FCPW80-2 could not only upregulate the expression of p-p65 and p-IκB-α, but also cause the translocation of nuclear factor-kappa B (NF-κB) p65 from cytosol to nuclei in RAW264.7 macrophages. The results demonstrated that MAPK and NF-κB signalling pathways participatedin FCPW80-2-induced macrophage activation and FCPW80-2 could be developed as a potential immunomodulating functional food.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Immunomodulatory : CK(2249) : AC(733)
Additional Keywords : Polysaccharides : CK(5) : AC(3)

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