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Abstract Title:

A combination of valerian and lemon balm is effective in the treatment of restlessness and dyssomnia in children.

Abstract Source:

Phytomedicine. 2006 Jun ;13(6):383-7. Epub 2006 Feb 17. PMID: 16487692

Abstract Author(s):

S F Müller, S Klement

Article Affiliation:

S F Müller

Abstract:

Efficacy and tolerability of a combined valerian/lemon balm preparation were investigated in an open, multicentre study in children less than 12 years suffering from restlessness and nervous dyskoimesis. Patients were dosed individually by the investigators. In total, 918 children were evaluated for therapeutic efficacy and tolerability. A distinct and convincing reduction in severity was found for all symptoms in the investigators' and parents' ratings. The core symptoms dyssomnia and restlessness were reduced from"moderate/severe"to"mild"or"absent"in most of the patients. In total, 80.9% of the patients who suffered from dyssomnia experienced an improvement for this symptom and 70.4% of the patients with restlessness improved clearly. For the other listed symptoms the total improvement was 37.8% on average. Both, parents and investigators assessed efficacy as to be"very good"or"good"(60.5% and 67.7%, respectively). The tolerability of Euvegal forte was considered as"good"(in 96.7% of the patients it was judged to be"very good"or"good"). No study medication-related adverse events occurred. In conclusion, Euvegal forte was effective in the treatment of younger children with restlessness and dyssomnia and it was very well tolerated.

Study Type : Human Study

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