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Abstract Title:

Mitigating Perspectives of Asiatic acid in the Renal derangements of Streptozotocin-Nicotinamide induced Diabetic Rats.

Abstract Source:

Cardiovasc Hematol Agents Med Chem. 2020 Jan 31. Epub 2020 Jan 31. PMID: 32003703

Abstract Author(s):

Swapna Kalidhindi, Veera Venkata Sathibabu Uddandrao, Vadivukkarasi Sasikumar, Nivedha Raveendran, Saravanan Ganapathy

Article Affiliation:

Swapna Kalidhindi

Abstract:

BACKGROUND: The present study was convened to evaluate the mitigating effects of Asiatic acid (AA), on the changes in carbohydrate metabolism, insulin signaling molecules and renal function markers in streptozotocin (STZ)-nicotinamide (NAD) induced diabetic rats.

METHODS: AA (20 mg/kg BW) was supplemented orally to the diabetic rats for 42 days. The levels of plasma glucose, hemoglobin (Hb), glycosylated hemoglobin (HbA1c) insulin and renal function markers, carbohydrate metabolic enzymes in the kidney and insulin signaling molecules in skeletal muscle were measured.

RESULTS: The administration of AA elicited a significant decrease in the levels of plasma glucose, insulin resistance, HbA1c, urea, uric acid, creatinine, glycogen, glycogen synthase, glucose-6-phosphatase, and fructose-1,6-bisphosphatase and a significant increase of body weight development, insulin, Hb, hexokinase, and glycogen phosphorylase and mRNA expressions of insulin signaling molecule like insulin receptor 1, insulin receptor 2 and glucose transporter-4 in the STZ-NAD induced diabetic rats. Further, the protective effect of AA was evidenced by its histological annotation of the kidney tissues.

CONCLUSION: Hence, this study concluded that AA can protect against renal dysfunction by attenuating carbohydrate metabolic disorder and subsequently enhances glucose utilization and renal function in STZ-NAD-induced diabetic rats.

Study Type : Animal Study

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