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Abstract Title:

Resveratrol inhibits the proliferation of human melanoma cells by inducing G1/S cell cycle arrest and apoptosis.

Abstract Source:

Mol Med Rep. 2015 Jan ;11(1):400-4. Epub 2014 Oct 21. PMID: 25333673

Abstract Author(s):

Zhiyuan Wu, Bin Liu, Cailing E, Jie Liu, Qingyu Zhang, Juntao Liu, Nianping Chen, Rongyi Chen, Runzhi Zhu

Article Affiliation:

Zhiyuan Wu

Abstract:

Resveratrol (Res), a natural plant extract, is an effective inducer of cell apoptosis and cell cycle arrest in multiple carcinoma cell types, which has been demonstrated by its ability to inhibit the proliferation of multiple human tumor cells in vitro. Although Res possesses chemopreventive properties against several types of cancer, the molecular mechanism underlying its anticancer activity remains to be fully elucidated. The present study demonstrated that Res induced cell cycle arrest and inhibited the proliferation of human melanoma A375 (IC50=23µM after 48 h; P<0.05) and SK-MEL-31 (IC50=15µM after 48 h; P<0.05) cells. Western blot analysis demonstrated that Res induced the apoptosis of human melanoma A375 and SK-MEL-31 cells by upregulating the expression of Bcl-2-associated X protein and B-cell lymphoma 2, possibly via the p53 pathway and activation of caspase-9 and caspase-3.

Study Type : In Vitro Study

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Sayer Ji
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