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Abstract Title:

Randomized Clinical Trial for the Evaluation of Immune Modulation by Yogurt Enriched withβ-Glucans from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), in Children from Medellin, Colombia.

Abstract Source:

Int J Med Mushrooms. 2018 ;20(8):705-716. PMID: 30317947

Abstract Author(s):

Sandra Lorena Duque Henao, Sergio A Urrego, Andrea M Cano, Edwin A Higuita

Article Affiliation:

Sandra Lorena Duque Henao

Abstract:

Pattern recognition receptor (PRR) agonists are promising for use in modulating immune responses in clinical settings characterized by immune immaturity or deficiency.β-Glucans derived from Ganoderma lucidum have demonstrated immune-modulatory activity both in vitro and in vivo. To evaluate the immunomodulatory activity of orally administered β-glucans, a randomized, double-blinded, placebo-controlled clinical study was performed in asymptomatic children, aged3 to 5 years old, from Medellin, Colombia. Primary outcomes were the circulating CD8+ T lymphocyte and natural killer cell counts; secondary outcomes were circulating lymphocyte counts (total, CD3+, and CD4+ T cells), serum concentrations of total immunoglobulin A and cytokines, and various hematological parameters. The treatments were administered daily for 12 weeks, and physical and laboratory evaluations were performed at days 0 and 84. Children in the group receiving a yogurt with β-glucans presented a significantly higher absolute count of peripheral blood total lymphocytes (CD3+, CD4+,and CD8+ T cells) than that in the group receiving placebo. The interventions were safe and well tolerated; no abnormal increases in serum creatinine or hepatic aminotransferases occurred, and adherence was higher than 90% in the intervention groups. This study demonstrates that β-glucans from G. lucidum increase the frequency of immune system cells in the peripheral blood; these cells are critical in the defense against infectious threats in asymptomatic children 3 to 5 years old. These findings warrant longer controlled clinical trials that aim to evaluate the efficacy of β-glucans in preventing infections in healthy children and to define their potential to enhance lymphoid cell number and functions in various lymphoid immune deficiencies.

Study Type : Human Study

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