Article Publish Status: FREE
Abstract Title:

Network Comparison of Inflammation in Colorectal Cancer and Alzheimer's Disease.

Abstract Source:

Biomed Res Int. 2015 ;2015:205247. Epub 2015 Jul 26. PMID: 26273596

Abstract Author(s):

Sungjin Park, Seok Jong Yu, Yongseong Cho, Curt Balch, Jinhyuk Lee, Yon Hui Kim, Seungyoon Nam

Article Affiliation:

Sungjin Park

Abstract:

Recently, a large clinical study revealed an inverse correlation of individual risk of cancer versus Alzheimer's disease (AD). However, no explanation exists for this anticorrelation at the molecular level; however, inflammation is crucial to the pathogenesis of both diseases, necessitating a need to understand differing signaling usage during inflammatory responses distinct to both diseases. Using a subpathway analysis approach, we identified numerous well-known and previously unknown pathways enriched in datasets from both diseases. Here, we present the quantitative importance of the inflammatory response in the two disease pathologies and summarize signal transduction pathways common to both diseases that are affected by inflammation.

Study Type : Human In Vitro

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Sayer Ji
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