Abstract Title:

Seasonal variation in acute gouty arthritis: data from Nationwide Inpatient Sample.

Abstract Source:

Clin Rheumatol. 2015 Aug 9. Epub 2015 Aug 9. PMID: 26255189

Abstract Author(s):

Paras Karmacharya, Ranjan Pathak, Madan Raj Aryal, Smith Giri, Anthony A Donato

Article Affiliation:

Paras Karmacharya

Abstract:

INTRODUCTION: Studies describing seasonal variations in acute gouty arthritis note seasonal variation, but disagree on timing, with most showing a peak in spring months while others show peaks later in the year. Various theories on the effect of weather and immune system changes on the chronobiology of monosodium urate crystals' equilibrium and precipitation have been proposed. We aimed to shed light on this question by examining the seasonal variation in the incidence of acute gouty arthritis in the USA using a large inpatient database.

METHODS: We used the Nationwide Inpatient Sample (NIS) database to identify patients aged≥18 years with primarydiagnosis of acute gouty arthritis (International Classification of Diseases, 9th Revision, Clinical Modificationcode 274.01) from 2009-2011 during hospitalization. We used the Edwards recognition and estimation ofcyclic trend method to study the seasonal variation of the incidence of acute gout and z-test to compare theseasonal incidences.

RESULTS: A total of 28,172 hospitalizations with primary diagnosis of acute gouty arthritis were reported in the USA from 2009-2011. The peak incidence of acute gout was seen in November (peak/low ratio 1.34, 95 % CI 1.29-1.38, p < 0.05). The highest number of hospitalizations was observed in autumn months while the lowest incidence was observed in spring (28.12 vs. 23.13 %, p < 0.001).

CONCLUSION: The peak incidence of acute gout seems to be in the fall with its peak in the month of November. This seasonality may shed light into the pathophysiology of acute attacks and better management of patients with gout who are at risk of acute attacks.

Study Type : Human Study
Additional Links

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.