Effect of coffee in lipopolysaccharide-induced indoleamine 2,3-dioxygenase activation and depressive-like behaviour in mice.
J Agric Food Chem. 2016 Oct 3. Epub 2016 Aug 3. PMID: 27690418
Research has identified a potential inverse-correlation between coffee consumption and the risk of depression. The aim of this study was to investigate the effects of caffeinated coffee on lipopolysaccharide-induced depressive-like behaviours and inflammatory biomarkers in an in vivo model of depression in a C57BL/6J mouse model. The behavioural studies showed both caffeinated coffee to decrease immobility time in the tail suspension test (56.60± 9.17; p<0.0001) and the forced swimming test (caffeinated coffee 28.80± 5.93; p<0.0001) suggesting antidepressant-like activity. The effects of caffeinated coffee on the inflammatory biomarkers associated with depression supported the results observed in the behavioural studies. Statistically significant decreases in indoleamine 2,3-dioxygenase activity (p<0.001) and neopterin/biopterin ratio (p<0.001) were observed in animals pre-treated with caffeinated coffee 24 h post-lipopolysaccharide exposure in comparison to the lipopolysaccharide control group. In conclusion, this study has provided evidence to suggest that caffeinated coffee has antidepressant-like activities however further studies are required to fully investigate these effects.