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Article Publish Status: FREE
Abstract Title:

Vinegar-processedpromotes anti-angiogenic activity and reduces toxicity in zebrafish and rat models.

Abstract Source:

Pharm Biol. 2021 Dec ;59(1):410-417. PMID: 34027806

Abstract Author(s):

Wan Liao, Yi Chen, Zongping Zhu, Jiao Chen, Tianhui Gao, Boonjai Limsila, Yenchit Techadamrongsin, Lei Wang, Jiali Yu, Chaomei Fu, Rui Li

Article Affiliation:

Wan Liao

Abstract:

CONTEXT: Processing with vinegar could enhance the efficacy and reduce the toxicity ofValeton. (Zingiberaceae), a Chinese herbal medicine with anti-inflammatory and antitumor activities.

OBJECTIVE: This study investigated the vinegar processing effects by evaluating anti-angiogenic effect and toxicity ofthrough zebrafish and rat models.

MATERIALS AND METHODS: Zebrafish embryos (AB and FLk-GFP strain) were applied to evaluate toxicity, cardiotoxicity and anti-angiogenic activity of volatile oil, and water decoction of the raw and vinegar-processed.Meanwhile, a blood stasis syndrome rat model was applied to study the toxicity by measuring the ovarian and uterine coefficient.

RESULTS: volatile oil and its vinegar-processed products in zebrafish had an LCof 67.315 and 95.755 μg/mL, respectively.water decoction and its vinegar-processed products had an LCof 161.440 and 206.239 μg/mL, respectively. The toxicity of vinegar-processed products was significantly lower than the raw, and the development characteristic of zebrafish embryos at different times confirmed these results. The volatile oil of vinegar-processed products could inhibit the growth of intersegmental blood vessels at the dose of 20 μg/mL, while the raw materials did not exhibit such effect at the same concentration. The rat experiment also confirmed that the volatile oil could reduce toxicity of ovarian and uterine.

DISCUSSION AND CONCLUSIONS: The study indicated that processing using vinegar could decrease toxicity and increase anti-angiogenic activity of, which could be applied for clinical treatment. Further in-depth study on the synergism and detoxification mechanism of vinegar processing technology is needed.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Anti-Angiogenic : CK(347) : AC(272)

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