Abstract Title:

Environmental levels of triclosan and male fertility.

Abstract Source:

Environ Sci Pollut Res Int. 2017 Dec 7. Epub 2017 Dec 7. PMID: 29214481

Abstract Author(s):

Joanna Jurewicz, Michał Radwan, Bartosz Wielgomas, Paweł Kałużny, Anna Klimowska, Paweł Radwan, Wojciech Hanke

Article Affiliation:

Joanna Jurewicz


Triclosan is a synthetic chemical with broad antimicrobial activity that has been used extensively in consumer products, including personal care products, textiles, and plastic kitchenware, although the exposure which is widespread evidence from human studies is scarce. Our study aims to investigate the relationship between triclosan exposure and male fertility. Triclosan (TCS) urinary concentrations were measured using gas chromatography coupled with tandem mass spectrometry in 315 men recruited from a male reproductive health clinic with normal sperm concentration (≥ 15 mln/ml) (WHO 2010) under 45 years of age. Participants were interviewed and provided a semen sample. TCS was detected in 84.13% of urine samples, with a median concentration of 2.83 μg/l (2.57 μg/g creatinine). A multiple linear regression analysis showed a positive association between the urinary concentrations of triclosan 50th-75th percentile and ≥ 50 percentile and percentage of sperm with abnormal morphology (p = 0.016 and p = 0.002, respectively). The study provides evidence that exposure to triclosan is associated with poorer semen quality. Future studies areneeded to confirm these findings.

Study Type : Human Study
Additional Links
Problem Substances : Triclosan : CK(157) : AC(45)

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