Organochlorine Levels in Plasma and Risk of Multiple Myeloma.
J Occup Environ Med. 2018 Oct ;60(10):911-916. PMID: 30289833
OBJECTIVE: The aim of this study was to estimate the association between organochlorine pesticides and polychlorinated biphenyls (PCBs) and multiple myeloma (MM).
METHODS: The risk of MM from organochlorine compounds was examined in a population-based case-control study in British Columbia, Canada. Congeners of PCBs and pesticides or pesticide metabolites were measured in plasma of 325 cases and 327 controls.
RESULTS: Most organochlorine analytes showed a significant association with MM. The strongest association (highest vs lowest quartile) was oxychlordane (odds ratio = 7.44; 95% confidence interval = 4.19 to 13.21). No heterogeneity was detected between organochlorines levels and MM subtypes. Only oxychlordane and β-hexachlorocyclohexane (β-HCCH) were identified as significant independent predictors of MM.
CONCLUSION: Our study provides evidence that organochlorines contribute to the risk of MM.