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Abstract Title:

Study of the Effects and Mechanisms of Ginsenoside Compound K on Myelosuppression.

Abstract Source:

J Agric Food Chem. 2019 Feb 6 ;67(5):1402-1408. Epub 2019 Jan 24. PMID: 30629411

Abstract Author(s):

Jiahong Han, Yu Wang, Enbo Cai, Lianxue Zhang, Yan Zhao, Nian Sun, Xiaoman Zheng, Siqi Wang

Article Affiliation:

Jiahong Han

Abstract:

Ginsenoside compound K (CK) is not a ginsenoside that naturally exists in Panax ginseng Meyer. However, CK is a major metabolite of ginsenoside Rb, Rb, or Rc in the intestine under the effects of bacteria. In this study, we first investigated the effects of CK on myelosuppression in mice induced by cyclophosphamide (CTX). The respective quantities of white blood cells, blood platelets, and bone marrow nucleated cells (BMNCs) were determined to be 8.54± 0.91 (10/L), 850.90± 44.11 (10/L), and 1.45± 0.22 (10/L) in the CK-H group by detecting peripheral blood cells and BMNCs. CK-H and CK-L both increased the thymus index by up to 0.62± 0.06 (mg/g) and 0.52 ± 0.09 (mg/g), respectively, and significantly increased the yields of colony formation units-granulocyte monocyte and colony formation units-megakaryocytic. According to our study, CK could control apoptosis and promote cells to enter the normal cell cycle by the bcl-2/baxsignaling pathway and MEK/ERK signaling pathway. Therefore, the BMNCs could proliferate and differentiate normally after entering the normal cell cycle. So the peripheral blood cells could show a trend of returning to normal. The recovery of peripheral blood cells resulting in the level of cytokinestended to normal. This process may be the mechanisms of CK on myelosuppression. This study provides a reference for ginseng in the treatment of myelosuppression.

Study Type : In Vitro Study

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