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Abstract Title:

Curcumin inhibits the formation of atherosclerosis in ApoEmice by suppressing cytomegalovirus activity in endothelial cells.

Abstract Source:

Life Sci. 2020 Jul 1:117658. Epub 2020 Jul 1. PMID: 32621921

Abstract Author(s):

Ya-Li Lv, Yangjie Jia, Zirui Wan, Zhuo-Ling An, Song Yang, Fei-Fei Han, Li-Li Gong, Ling-Ling Xuan, Lu-Lu Ren, Wen Zhang, He Liu, Li-Hong Liu

Article Affiliation:

Ya-Li Lv

Abstract:

BACKGROUND: Curcumin (Cur) is a hydrophobic polyphenol compound derived from the rhizome of the herb Curcuma longa. Cur has a wide spectrum of biological and pharmacological activities. It has been shown that human cytomegalovirus (HCMV) infection was an important risk factor for atherosclerosis (AS) and Cur exhibited an outstanding anti-HCMV effect. However, anti-AS effects of Cur remain unclear when HCMV infected endothelial cells.

AIMS: This study will investigate the anti-AS activities and mechanism of Cur,when HCMV infected in vivo and in vitro.

MATERIALS AND METHODS: Cur (0.5, 1, and 2 μM) was used to explore the anti-AS activities and mechanism after HCMV infected endothelial cells in vitro. ApoEmice were fed a high fat and cholesterol diet (HD) and given 4000,000 copies/mouse MCMV infection by intraperitoneal and treated with ganciclovir (5 mg/kg/d), Cur (25, 15 mg/kg/d) for 10 weeks in vivo.

KEY FINDINGS: As our results showed that Cur inhibited CMV replication and proliferation, reduced the intracellular ROS overproduction, decreased the release of inflammatory cytokines, down-regulated the level of HMGB1-TLRS-NF-κB signaling pathway-related proteins in vitro experiments. Cur reduced the serum levels of LDL-C, TC and TG, significantly decreased the formation of atherosclerotic plaque in the aorta, reduced the lipid deposition in liver and inflammatory damage in heart, lung and kidney in vivo experiments.

SIGNIFICANCE: This study showed that Cur prevent AS progression by inhibiting CMV activity and CMV-induced HMGB1-TLRS-NF-κB signaling pathway.

Study Type : Animal Study

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Sayer Ji
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