Antibiofilm and Antivirulence Efficacies of Flavonoids and Curcumin Against.
Front Microbiol. 2019 ;10:990. Epub 2019 May 8. PMID: 31134028
Chaitany Jayprakash Raorane
is well adapted to hospital environments, and the persistence of its chronic infections is mainly due to its ability to form biofilms resistant to conventional antibiotics and host immune systems. Hence, the inhibitions of biofilm formation and virulence characteristics provide other means of addressing infections. In this study, the antibiofilm activities of twelve flavonoids were initially investigated. Three most active flavonoids, namely, fisetin, phloretin, and curcumin, dose-dependently inhibited biofilm formation by a referencestrain and by several clinical isolates, including four multidrug-resistant isolates. Furthermore, the antibiofilm activity of curcumin (the most active flavonoid) was greater than that of the well-known biofilm inhibitor gallium nitrate. Curcumin inhibited pellicle formation and the surface motility of. Interestingly, curcumin also showed antibiofilm activity againstand mixed cultures ofand.molecular docking of the biofilm response regulator BfmR showed that the binding efficacy of flavonoids with BfmR was correlated with antibiofilm efficacy. In addition, curcumin treatment diminishedvirulence in anmodel without cytotoxicity. The study shows curcumin and other flavonoids have potential for controlling biofilm formation by and the virulence of.