This study shows that vitamin-D deficiency in term neonates may predispose them to late-onset sepsis. - GreenMedInfo Summary
Role of Vitamin-D Deficiency in Term Neonates with Late-Onset Sepsis: A Case-Control Study.
J Trop Pediatr. 2019 Apr 21. Epub 2019 Apr 21. PMID: 31006010
Amit Agrawal
OBJECTIVE: To find the relationship between vitamin-D levels and late-onset sepsis (LOS) in term neonates.
METHODS: This case-control study was conducted in neonatal intensive care unit of a tertiary care teaching institution in central India. Full-term neonates with culture-proven LOS were taken as cases. Maternal and neonatal demography, clinical examination and investigations were recorded. Correlation of vitamin-D deficiency (<20 ng/ml) with LOS was assessed.
RESULTS: Total 225 term neonates including 175 cases and 50 controls were included. Maternal and neonatal demographic profile was comparable. The mean vitamin-D level in cases (12.28 ± 6.11 ng/ml) was significantly lower than that in controls (14.88 ± 7.2 ng/ml) (p = 0.002). Total 151 (86.29%) neonates out of 175 cases and 37 (74%) out of 50 controls had the vitamin-D deficiency (p = 0.00003). On multiple regression analysis, neonatal sepsis (p = 0.00003) was found to be significantly associated with vitamin-D deficiency.
CONCLUSION: This study shows that vitamin-D deficiency in term neonates may predispose them to LOS.
