Abstract Title:

Cytotoxic effects of butanolic extract from Pfaffia paniculata (Brazilian ginseng) on cultured human breast cancer cell line MCF-7.

Abstract Source:

Exp Toxicol Pathol. 2008 May 15. PMID: 18485683

Abstract Author(s):

Marcia Kazumi Nagamine, Tereza Cristina da Silva, Patrícia Matsuzaki, Kátia Cristina Pinello, Bruno Cogliati, Célia Regina Pizzo, Gokithi Akisue, Mitsue Haraguchi, Silvana Lima Górniak, Idércio Luiz Sinhorini, Kurapati Venkata Kesava Rao, José Alexandre Marzagão Barbuto, Maria Lúcia Zaidan Dagli

Abstract:

Roots of Pfaffia paniculata have been well documented for multifarious therapeutic values and have also been used for cancer therapy in folk medicine. This study has been performed in a human breast tumor cell line, the MCF-7 cells. These are the most commonly used model of estrogen-positive breast cancer, and it has been originally established in 1973 at the Michigan Cancer Foundation from a pleural effusion taken from a woman with metastatic breast cancer. Butanolic extract of the roots of P. paniculata showed cytotoxic effect MCF-7 cell line, as determined with crystal violet assay, cellular death with acridine orange/ethidium bromide staining, and cell proliferation with immunocytochemistry of bromodeoxyuridine (BrdU). Subcellular alterations were evaluated by electron microscopy. Cells treated with butanolic extract showed degeneration of cytoplasmic components and profound morphological and nuclear alterations. The results show that this butanolic extract indeed presents cytotoxic substances, and its fractions merit further investigations.

Study Type : In Vitro Study

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