Potential Therapeutic Role of Dietary Supplementation withon the Erectile Function of Obese Rats Fed a Hypercaloric Diet.
Oxid Med Cell Longev. 2020 ;2020:3293065. Epub 2020 Jun 30. PMID: 32685091
Anderson Fellyp Avelino Diniz
, an important source of bioactive compounds, is a multicellular, filamentous cyanobacterium rich in high-quality proteins, vitamins, minerals, and antioxidants. Due to its nutrient composition, the alga is considered a complete food and is recognized for its anti-inflammatory, antioxidant, antiobesity, and reproprotective effects. All of which are important for prevention and treatment of organic and metabolic disorders such as obesity and erectile dysfunction. The aim of this study was to investigate the modulatory role offood supplementation and the mechanisms of action involved in reversing the damage caused by a hypercaloric diet on the erectile function of rats. The animals were divided into a standard diet group (SD,= 5); a hypercaloric diet group (HCD,= 5); a hypercaloric diet group supplemented withat doses of 25 (HCD+SP25,= 5), 50 (HCD+SP50,= 5), and 100 mg/kg (HCD+SP100,= 5); and a hypercaloric diet group subsequently fed a standard diet (HCD+SD,= 5). In the rats fed a hypercaloric diet, dietary supplementation witheffectively increased the number of erections while decreasing latency to initiate penile erection. Additionally,increases NO bioavailability, reduces inflammation by reducing the release of contractile prostanoids, enhances the relaxation effect promoted by acetylcholine (ACh), restores contractile reactivity damage and cavernous relaxation, reduces reactive oxygen species (ROS), and increases cavernous total antioxidant capacity (TAC). Food supplementation withthus restores erectile function in obese rats, reduces production of contractile prostanoids, reduces oxidative stress, and increases NO bioavailability. Food supplementation withthus emerges as a promising new therapeutic alternative for the treatment of erectile dysfunction as induced by obesity.