Abstract Title:

Suppressive effect of flavonoids from Korean Citrus aurantium L. on the expression of inflammatory mediators in L6 skeletal muscle cells.

Abstract Source:

Phytother Res. 2012 Dec ;26(12):1904-12. Epub 2012 Mar 19. PMID: 22431150

Abstract Author(s):

Jin-A Kim, Hyeon-Soo Park, Sang-Rim Kang, Kwang-Il Park, Do-Hoon Lee, Arulkumar Nagappan, Sung-Chul Shin, Won-Sup Lee, Eun-Hee Kim, Gon-Sup Kim

Article Affiliation:

Jin-A Kim


Citrus fruits (Citrus aurantium L.) have long been used as a traditional herbal medicine. The benefits of the flavonoids found in Citrus aurantium L. include anti-inflammation, anti-cancer, anti-viral and anti-bacterial activities, and enhancement of the immune response. The study investigated the effect of the flavonoids isolated from Citrus aurantium L. native to Korea on the production of pro-inflammatory mediators by blocking signal transduction mediated by nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs) in lipopolysaccharide (LPS)-induced L6 skeletal muscle cells. The flavonoids decreased the production of inducible nitric oxide synthase, cyclooxygenase-2, interleukin-6 and tumor necrosis factor-alpha by suppressing NF-κB and MAPKs signal pathwaysin LPS-induced L6 skeletal muscle cells. These findings suggest that the flavonoids isolated from Korea Citrus aurantium L. might have anti-inflammatory effects that regulate the expression of inflammatory mediators in L6 skeletal muscle cells.

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