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Article Publish Status: FREE
Abstract Title:

Survivin Promotes Piperlongumine Resistance in Ovarian Cancer.

Abstract Source:

Front Oncol. 2019 ;9:1345. Epub 2019 Nov 29. PMID: 31850227

Abstract Author(s):

Xing-Wei Nan, Li-Hua Gong, Xu Chen, Hai-Hong Zhou, Piao-Piao Ye, Yang Yang, Zi-Hao Xing, Meng-Ning Wei, Yao Li, Sheng-Te Wang, Kun Liu, Zhi Shi, Xiao-Jian Yan

Article Affiliation:

Xing-Wei Nan

Abstract:

Ovarian cancer is one of the most fatal female malignancies while targeting apoptosis is critical for improving ovarian cancer patients' lives. Survivin is regarded as the most robust anti-apoptosis protein, and its overexpression in ovarian cancer is related to poor survival and apoptosis resistance. Piperlongumine (PL) extracted from peppers is defined as an active alkaloid/amide and exhibits a broad spectrum of antitumor effects. Here, we demonstrate that PL induces the rapid depletion of survivin protein levels via reactive oxygen species (ROS)-mediated proteasome-dependent pathway, while exerting a remarkable inhibitory influence on the proliferation of ovarian cancer cells. Overexpression of survivin raises the survival rate of ovarian cancer cells to PL. Moreover, PL inhibits ovarian cancer cells xenograft tumor growth and downregulates survivin. Our findings reveal a previously unrecognized mechanism of PL in suppressing survivin expression as well as survivin promotes piperlongumine resistance in ovarian cancer and suggest that ROS-mediated proteasome-dependent pathway can be exploited to overcome apoptosis resistance triggered by aberrant expression of survivin.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846)

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