Sweet Lime (C. limetta) antagonizes the hypertensive effect of Angiotensin II. - GreenMedInfo Summary

Ethnopharmacological relevance: Citrus limetta Risso (Rutaceae) is widely used in Mexico for healing purposes, among them as antihypertensive treatment.Aim of the study:To assess the antihypertensive effect of C. limetta leaves as one of its ethnomedical uses.Materials and methods:the acute response of blood pressure to angiotensin II administration was measured in mice. Additionally, the acute oral toxicity profiles were determined. RESULTS: The findings of the current investigation showed that different concentrations of the aqueous extract prevented the raise of systolic blood pressure (p