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Abstract Title:

Synergistic antimicrobial combination of carvacrol and thymol impairs single and mixed-species biofilms ofand.

Abstract Source:

Biofouling. 2020 11 ;36(10):1256-1271. Epub 2021 Jan 12. PMID: 33435734

Abstract Author(s):

Thirukannamangai Krishnan Swetha, Arumugam Vikraman, Chari Nithya, Nagaiah Hari Prasath, Shunmugiah Karutha Pandian

Article Affiliation:

Thirukannamangai Krishnan Swetha

Abstract:

andare important opportunistic human pathogens, which form mixed-species biofilms and cause recalcitrant device associated infections in clinical settings. Further to many reports suggesting the therapeutic potential of plant-derived monoterpenoids, this study investigated the interaction of the monoterpenoids carvacrol (C) and thymol (T) against mono- and mixed-species growth ofand. C and T exhibited synergistic antimicrobial activity. The time-kill study and post-antimicrobial effect results revealed the effective microbicidal action of the C + T combination. Filamentation, surface coating assays and live-dead staining of biofilms determined the anti-hyphal, antiadhesion, and anti-biofilm activities of the C + T combination, respectively. Notably, this combination killed highly tolerant persister cells of mono-species and mixed-species biofilms and demonstrated less risk of resistance development. The collective data suggest that the C + T combination could act as an effective therapeutic agent against biofilm associated mono-species and mixed-species infections ofand

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