Synergistic Antioxidant and Antibacterial Activity of Curcumin-C3 Encapsulated Chitosan Nanoparticles.
Curr Pharm Des. 2020 Jun 9. Epub 2020 Jun 9. PMID: 32516096
Desu Naveen Kumar Reddy
BACKGROUND: Recent studies have focused on nanoformulations of curcumin to enhance its solubility and bioavailability. The medicinal properties of curcumin-C3 complex which is a combination of three curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin) is less explored.
OBJECTIVE: The aim of this study was to prepare curcumin-C3 encapsulated in chitosan nanoparticles, characterize and evaluate their antioxidant and antibacterial potential.
METHODS: Ionic gelation method was used to prepare curcumin-C3 nanoparticles and were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, transmission electron microscopy, nanoparticle tracking analysis. In vitro assays were performed to assess drug release, antioxidant and antibacterial activities.
RESULTS: Curumin-C3-chitosan nanoparticle showed an increased entrapment efficiency of>90%, drug release and an improved antioxidant potential. Moreover, curumin-C3-chitosan nanoparticle showed stronger inhibition of Escherichia coli and Staphylococcus aureus.
CONCLUSION: Chitosan is a suitable carrier for curcumin-C3 nanoparticle and can be used as a drug delivery system in the treatment of inflammatory and bacterial diseases.