Systematic Review with Meta-Analysis:DSM 17938 for Treating Acute Gastroenteritis in Children. An Update.
Nutrients. 2019 Nov 14 ;11(11). Epub 2019 Nov 14. PMID: 31739457
The effectiveness ofDSM 17938 () for the management of acute gastroenteritis (AGE) has been recently questioned. We performed a systematic review to update evidence onfor treating AGE in children. We searched MEDLINE, EMBASE, the Cochrane Library databases, and additional data sources from January 2016 (end of search for our 2016 systematic review) to August 2019. The primary outcomes were stool volume and duration of diarrhea. Four RCTs were included. None of them evaluated stool volume. Compared with placebo or no treatment,reduced diarrhea duration (four RCTs,= 347, mean difference, MD -0.87 days, 95% CI [-1.43, -0.31]).use was also associated with a reduced duration of hospitalization (three RCTs,= 284, MD -0.54 days, 95% CI [-1.09, 0.0]). The small effect sizes of limited clinical relevance and methodological limitations of the included trials should be noted when interpreting these findings.