Abstract Title:

Screening of anti-HIV-1 inophyllums by HPLC-DAD of Calophyllum inophyllum leaf extracts from French Polynesia Islands.

Abstract Source:

Anal Chim Acta. 2008 Aug 22;624(1):147-53. Epub 2008 Jul 9. PMID: 18706320

Abstract Author(s):

Frédéric Laure, Phila Raharivelomanana, Jean-François Butaud, Jean-Pierre Bianchini, Emile M Gaydou

Article Affiliation:

Biodiversité Terrestre et Marine, Université de la Polynésie Française, BP 6570, 98702 Faa'a, Tahiti, French Polynesia.

Abstract:

Various pyranocoumarins, calophyllolide, inophyllums B, C, G(1), G(2) and P, from Calophyllum inophyllum (Clusiaceae) leaves of French Polynesia (Austral, Marquesas, Society and Tuamotu archipelagos) have been determined in 136 leaf extracts using a high pressure liquid chromatography-UV-diode array detection (HPLC-UV-DAD) technique. Results show a wide range in chemical composition within trees growing on eighteen islands. The use of multivariate statistical analyses (PCA) shows geographical distribution of inophyllums and indicate those rich in HIV-1 active (+)-inophyllums. Inophyllum B and P contents (0.0-39.0 and 0.0-21.8 mg kg(-1), respectively) confirm the chemodiversity of this species within the large area of French Polynesia. The study suggests the presence of interesting chemotypes which could be used as plant source for anti-HIV-1 drugs.

Study Type : In Vitro Study

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