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Abstract Title:

Tangeretin: a mechanistic review of its pharmacological and therapeutic effects.

Abstract Source:

J Basic Clin Physiol Pharmacol. 2020 Apr 23. Epub 2020 Apr 23. PMID: 32329752

Abstract Author(s):

Milad Ashrafizadeh, Zahra Ahmadi, Reza Mohammadinejad, Elham Ghasemipour Afshar

Article Affiliation:

Milad Ashrafizadeh

Abstract:

To date, a large number of synthetic drugs have been developed for the treatment and prevention of different disorders, such as neurodegenerative diseases, diabetes mellitus, and cancer. However, these drugs suffer from a variety of drawbacks including side effects and low efficacy. In response to this problem, researchers have focused on the plant-derived natural products due to their valuable biological activities and low side effects. Flavonoids consist of a wide range of naturally occurring compounds exclusively found in fruits and vegetables and demonstrate a number of pharmacological and therapeutic effects. Tangeretin (TGN) is a key member of flavonoids that is extensively found in citrus peels. It has different favorable biological activities such as antioxidant, anti-inflammatory, antitumor, hepatoprotective, and neuroprotective effects. In the present review, we discuss the various pharmacological and therapeutic effects of TGN and then, demonstrate how this naturally occurring compound affects signaling pathways to exert its impacts.

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